Southern SARMs ( Selective Androgen Receptor Modulators ) - How Testosterone plays important role in sex hormone

Southern SARMs (Selective Androgen Receptor Modulators) the complex effects of testosterone, investigators found, depend partly on its conversion in the body to a type of estrogen. The insights will help guide the development of better ways to diagnose and treat men who don’t produce enough natural testosterone. Testosterone is a sex hormone that plays important roles in the body. In men, it’s thought to regulate sex drive (libido), bone mass, fat distribution, muscle mass and strength, and the production of red blood cells and sperm. A small amount of circulating testosterone is converted to estradiol, a form of estrogen. As men age, they often make less testosterone, and so they produce less estradiol as well. Thus, changes often attributed to testosterone deficiency might be partly or entirely due to the accompanying decline in estradiol.

The hormone is now widely prescribed to men whose bodies naturally produce low levels. But the levels at which testosterone deficiency become medically relevant still aren’t well understood. Normal testosterone production varies widely in men, so it’s difficult to know what levels have medical significance. The hormone’s mechanisms of action are also unclear.

To control hormone levels, the researchers first gave the participants injections of a drug that suppressed their normal testosterone and estradiol production. Blood was taken to measure hormone levels, and questionnaires were given to assess physical function, health status, vitality, and sexual function. Body fat and muscle measurements were also taken at the beginning and end of the 16 weeks.

The researchers found that the dose of testosterone required to produce different effects in the body varied widely. The influence of testosterone and estradiol also differed. As the testosterone gel dose was reduced, the scientists showed, reductions in lean mass, muscle size, and leg-press strength resulted from decreases in testosterone itself. In contrast, increases in body fat were due to the related declines in estradiol. Both testosterone and estradiol levels were associated with libido and erectile function.

1. Low sex drive

Testosterone plays a key role in libido (sex drive) in men. Some men may experience a decline in sex drive as they age. However, someone with low T will likely experience a more drastic drop in their desire to have sex.

2. Difficulty with erection

Testosterone stimulates a man’s sex drive, it also aids in achieving and maintaining an erection. Testosterone alone doesn’t cause an erection, but it stimulates receptors in the brain to produce nitric oxide. Nitric oxide is a molecule that helps trigger a series of chemical reactions necessary for an erection to occur. When testosterone levels are too low, a man may have difficulty achieving an erection prior to sex or having spontaneous erections (for example, during sleep).

3. Low semen volume

Testosterone plays a role in the production of semen, which is the milky fluid that aids in the motility of sperm. Men with low T will often notice a decrease in the volume of their semen during ejaculation.

4. Hair loss

Testosterone plays a role in several body functions, including hair production. Balding is a natural part of aging for many men. Men with low T may experience a loss of body and facial hair, as well.

5. Fatigue

Men with low T have reported extreme fatigue and decrease in energy levels.Low T if you’re tired all of the time despite getting plenty of sleep or if you’re finding it harder to get motivated to exercise.

6. Loss of muscle mass

Testosterone plays a role in building muscle, men with low T might notice a decrease in muscle mass. Testosterone affects muscle mass, but not necessarily strength or function.

7. Increased body fat

Men with low T may also experience increases in body fat. In particular, they sometimes develop gynecomastia, or enlarged breast tissue. This effect is believed to occur due to an imbalance between testosterone and estrogen within men.

8. Decreased bone mass

Testosterone helps produce and strengthen bone. So men with low T, especially older men, have lower bone volume and are more susceptible to bone fractures.

9. Mood changes

Men with low T can experience changes in mood. Because testosterone influences many physical processes in the body, it can also influence mood and mental capacity. Research suggests that men with low T are more likely to face depression, irritability, or a lack of focus.

10. Affected memory

Both testosterone levels and cognitive functions particularly memory decline with age. As a result, doctors have theorized that lower testosterone levels could contribute to affected memory. Testosterone supplementation with improved memory in men with low levels.

11. Smaller testicle size

Low testosterone levels in the body can contribute to smaller-than-average sized testicles. Because the body requires testosterone to develop the penis and testicles, low levels could contribute to a disproportionately smaller penis or testicles compared to a man with normal testosterone levels.

12. Low blood counts

Doctors have linked low testosterone with an increased risk for anemia. Testosterone gel to anemic men who also had low testosterone, they saw improvements in blood counts compared to men who used a placebo gel. Some of the symptoms anemia can cause include problems concentrating, dizziness, leg cramping, problems sleeping, and an abnormally rapid heart rate.

Southern SARMs - Selective Androgen Receptor Modulators Therapies with Advantages

Southern SARMs most recent discovery of non-steroidal says that selective androgen receptor modulators (SARMs) provides a promising alternative for testosterone replacement therapies with advantages including oral bio-availability, flexibility of structural modification, androgen receptor specificity, tissue selectivity, and the lack of steroid-related side effects.

The beneficial effects of testosterone on muscle, bone, and physique have been known for over a century. Yet testosterone and its esters are approved for only a limited number of therapeutic applications, including primary or hypogonadotropic hypogonadism and delayed puberty. Testosterone and structurally-related anabolic steroids have been demoted to the therapy of final resort for anemia, endometriosis, and metastatic breast cancer owing to the recent development and widespread clinical use of more effective therapies. Recent interest in using testosterone as hormone replacement in aging men or in age-related frailty has been slowed because of widespread concerns related to the effects of testosterone on the prostate, serum lipids, and cardiovascular system. The discovery and clinical development of selective estrogen receptor modulators (SERMs) transformed the therapeutic use of estrogens. Non steroidal selective androgen receptor modulators (SARMs) with the ability to selectively stimulate or maintain muscle and bone mass with lesser pharmacologic effects in the prostate are now leading a similar revolution in the therapeutic use of androgens.

Circulating testosterone is synthesized and secreted by the Leydig cells in the testes. Circulating testosterone is essential for the differentiation and growth of male accessory reproductive organs (e.g., prostate and seminal vesicles), control of male sexual behavior, and the development and maintenance of male secondary characteristics that involve muscle, bone, larynx, and hair. For decades, androgens have been primarily used for hormonal replacement in hypogonadal men. Whereas severe hypogonadism is uncommon, disease and aging-related androgen insufficiency is much more frequent. Low endogenous testosterone concentrations are associated with sarcopenia and frailty arising from decreased fat-free mass, lessened muscle strength, and reduced bone mineral density (BMD). The potential benefits of testosterone replacement therapy include increase in BMD, improvement in body composition and strength, sexual function, cognitive function, and mood; however, the potential risks of such treatment, including those in the cardiovascular system, blood and prostate are routinely experienced. Large-scale and long-term clinical trials are needed to evaluate the risk–benefit ratio of testosterone replacement therapy in aging men. Another important line of research using testosterone is hormonally mediated male contraception. A variety of attempts have been made to produce pharmacologic, effective, reversible and side effect–free contraceptive methods for the male. Hormonal male contraception has only recently reached the stage of clinical development.

Bone is a living tissue, which is continuously being broken down and regenerated by osteoclasts and osteoblasts, respectively. AR ligands affect BMD by changing overall osteoblastic activity and osteoclastic activity, resulting from changes in the total number of each cell type and individual cell functional capacity. These actions are mediated directly by the AR and by paracrine and autocrine action. The underlying mechanisms for paracrine and autocrine action have been reviewed in detail elsewhere. Androgens seem to have the ability to decelerate the bone remodeling cycle and tilt the focal balance of the cycle toward bone formation. The loss of androgens is thought to increase the rate of bone remodeling by removing restraining effects on osteoblastogenesis and osteoclastogenesis. Also, androgens exert dual effects on the lifespan of mature bone cells, with anti-apoptotic effects on osteoblasts and osteoclasts and pro-apoptotic effects on osteoclasts. DHT also stimulates osteoblast proliferation under experimental conditions

Georgia Southern SARMs Define Symptoms to Recognize Low Testosterone

Georgia Southern SARMs ( Selective Androgen Receptor Modulators ) Symptom for low testosterone in women can be similar to other conditions such as Hypothyroidism, Depression, Iron deficiency, and low levels of other hormones such as estrogen and progesterone so it’s always important to have all hormone levels checked, including thyroid, to determine what’s causing symptoms. Lab tests will give the full “story” of what’s going on.

Though it’s much less common, some women have too much testosterone and it’s just as important to see a doctor for this as it is for low testosterone. Symptoms can include:

l Excess body hair

l Excess hair on chin or upper lip

l Deepening voice

l Acne and/or oily skin

l Balding around hairline

l Increased muscle mass/change in body shape

l Absence of periods

Research and studies in the past on low testosterone in women were not consistent and findings were varied regarding testosterone therapy for women. For example, one study associated an increase in abdominal weight gain after taking testosterone, however those results have been deemed “flawed” because the women participating had other hormonal imbalances going on that were not taken into consideration.

More recently though, research is showing that testosterone therapy is important and plays a big role in both how women feel, especially in regards to their libido and staying fit, lean, and active, and in their long-term health.

Women who were given testosterone therapy lost two times more body fat and gained more muscle mass than women given a placebo. The women taking the testosterone therapy gained considerable lean muscle mass over a nine-month period (which helps you to lose weight). Both groups were on the same low-fat diet and exercise regime during the course of study.

Additionally, studies suggest that a deficiency in testosterone can be a “key predictive factor” for heart disease in menopausal women or women who have had hysterectomies, and that these women have three times more risk in developing cardiovascular disease – so treating low testosterone in women is important.

Women only need a very small percentage of testosterone supplementation compared to what men need. When testosterone is balanced, women report that they feel more like they did when they were younger and have pep in their step again, with better mood and motivation. Entering the hormonal shifts that occur with peri-menopause and menopause can really have an impact on life and it’s always rewarding to feel like oneself again!

The Renewed Vitality practitioners are experts in hormone balancing. Our lab testing is much more comprehensive than what is traditionally done by most doctors so that all areas of deficiency and imbalances can be identified so that you can feel your very best. 

Southern SARMs - Ways How Selective Androgen Receptor Modulators Boosts Your Metabolism

Southern SARMs Metabolism is a term that describes all the chemical reactions in your body. These chemical reactions keep your body alive and functioning. However, the word metabolism is often used interchangeably with metabolic rate, or the number of calories you burn.The higher it is, the more calories you burn and the easier it is to lose weight and keep it off. Having a high metabolism can also give you energy and make you feel better. Here are 10 easy ways to increase your metabolism.

1. Eat Plenty of Protein at Every Meal

Eating food can increase your metabolism for a few hours. This is called the thermic effect of food (TEF). It’s caused by the extra calories required to digest, absorb and process the nutrients in your meal.

2. Drink More Cold Water

People who drink water instead of sugary drinks are more successful at losing weight and keeping it off. This is because sugary drinks contain calories, so replacing them with water automatically reduces your calorie intake. However, drinking water may also temporarily speed up your metabolism. This calorie-burning effect may be even greater if you drink cold water, as your body uses energy to heat it up to body temperature.

3. Do a High-Intensity Workout

High-intensity interval training (HIIT) involves quick and very intense bursts of activity. It can help you burn more fat by increasing your metabolic rate, even after your workout has finished. This effect is believed to be greater for HIIT than for other types of exercise. What’s more, HIIT has also been shown to help you burn fat.

4. Lift Heavy Things

Muscle is more metabolically active than fat, and building muscle can help increase your metabolism. This means you will burn more calories each day, even at rest. Lifting weights will also help you retain muscle and combat the drop in metabolism that can occur during weight loss. Overweight women were placed on a diet of 800 calories per day, along with either no exercise, aerobic exercise or resistance training. After the diet, the women who did the resistance training maintained their muscle mass, metabolism and strength. The others lost weight, but also lost muscle mass and experienced a decrease in metabolism.

5. Stand up More

Sitting too much is bad for your health.Some health commentators have even dubbed it “the new smoking.” This is partly because long periods of sitting burn fewer calories and can lead to weight gain. In fact, compared to sitting, an afternoon of standing up at work can burn an extra 174 calories.If you have a desk job, try standing up for short periods to break up the length of time you spend sitting down. You can also invest in a standing desk.

6. Drink Green Tea or Oolong Tea

Green tea and oolong tea have been shown to increase metabolism by 4–5%. These teas help convert some of the fat stored in your body into free fatty acids, which may increase fat burning by 10–17%. As they are low in calories, drinking these teas may be good for both weight loss and weight maintenance. It’s thought their metabolism-boosting properties may help prevent the dreaded weight loss plateau that occurs due to a decrease in metabolism. However, some studies find that these teas do not affect metabolism. Therefore, their effect may be small or only apply to some people.

7. Eat Spicy Foods

Peppers contain capsaicin, a substance that can boost your metabolism. However, many people can’t tolerate these spices at the doses required to have a significant effect. Acceptable doses, predicted that eating peppers would burn around 10 additional calories per meal.The effects of adding spices to your food may be quite small. However, it may lead to a slight advantage when combined with other metabolism-boosting strategies.

8. Get a Good Night’s Sleep

Lack of sleep is linked to a major increase in the risk of obesity.This may partly be caused by the negative effects of sleep deprivation on metabolism. Lack of sleep has also been linked to increased blood sugar levels and insulin resistance, which are both linked to a higher risk of developing type 2 diabetes.It’s also been shown to boost the hunger hormone ghrelin and decrease the fullness hormone leptin.

Southern SARMs ( Selective Androgen Receptor Modulators ) - Natural ways to boost Testosterone

Southern SARMs defines various ways to add zing to your meals are onions and garlic are your allies in the kitchen and in the bedroom. They help you make more and better sperm. Both raise levels of a hormone that triggers your body to make testosterone. And both have high levels of natural plant chemical called flavonoids, which safeguard your li'l swimmers against damage. 

Pile on the Protein i.e Lean beef, chicken, fish, and eggs are some of your options. Tofu, nuts, and seeds have protein, too. Try to get about 5 to 6 ounces per day, although the ideal amount for you depends on your age, sex, and how active you are. When you don't eat enough of these foods, your body makes more of a substance that binds with testosterone, leaving you with less T available to do its job.

Go Fish Fatty kinds like salmon, tuna, and mackerel are rich with vitamin D. It's a natural testosterone booster because it plays a crucial role in hormone production. For more Magnesium this mineral blocks a protein from binding with testosterone. The result? More of the usable man-stuff floating around in your blood. Spinach is packed with magnesium. Almonds, cashews, and peanuts are good sources, too. 

Order Oysters there's a reason why these mollusks are known for being great for fertility. They have almost five times your recommended daily dose of zinc. This mineral helps your body make testosterone. You can also get it in beef and beans. And it's often added to breakfast cereal. Pick Pomegranate and start your day with a glass of this ancient seedy fruit's juice instead of OJ. It lowers levels of stress hormones, such as cortisol, which helps raise levels of sex hormones including testosterone. And it can lower your blood pressure and put you in a better mood!

 

Diet Down a Mediterranean-style diet can help keep your weight in check and protect you from insulin resistance, which is related to lower T levels. And when your testosterone is low, your fat levels go up, which can lead to your body not using insulin well. You can break this cycle. Trade saturated fats for healthier ones such as olive oil, avocado, and nuts. Choose lean meats and whole grains. Eat lots of veggies and fruits.

 

Back Off the Beer it takes only 5 days of regular drinking for your testosterone level to drop. Alcohol may throw off many parts of your body's hormone system. Heavy drinkers can have shrunken testes, thin chest and beard hair, and higher levels of the female hormone estrogen.

 

Use Glass, Not Plastic be careful about what you store your leftovers in. Bisphenol-A (BPA) is a chemical found in some plastics, cans, and other food packaging. It can mess with your hormone-making process. After 6 months, men who worked around BPA every day had lower testosterone levels than men who didn't.

 

Build Your Strength focus your workouts on your muscles. Hit the weight room at the gym, or get a trainer to help you with a routine on the exercise machines. Cardio has its benefits, but it doesn't boost your testosterone like strength training can. Be careful to not overdo it. Too much exercise can take your T level in the other direction.

 

Get Enough ZZZs your body turns up the testosterone when you fall asleep. The levels peak when you start dreaming and stay there until you wake up. But daytime testosterone levels can drop up to 15% when you get only 5 hours of sleep. Aim for 7 or 8 hours every night, even if it means a shift in your schedule or a limit to your late-night plans.

 

Botox more men get Botox than any other procedure. It’s injected into your face and neck to treat lines. The goal is to make your skin look smoother and more refreshed. Botox is often used to soften crow's feet, forehead creases, and band lines in the neck. It also may help with migraines, heavy sweating, and muscle spasms in your neck and around your eyes.

Southern SARMs - How Selective Androgen Receptor Modulators protect muscle wastage

Southern SARMs or ‘Selective Androgen Receptor Modulators’, are a kind of research chemicals that are popular in the world of bodybuilding and gymming. These were initially designed to help cancer patients dealing with muscle loss which is a side-effect of radiation and chemotherapy.

SARMs protect muscle wastage, they quickly gained popularity among bodybuilders. Technically SARMs are research chemicals because they are still being studied. However, they are marked and sold as supplements. You should also know that SARMs are almost exclusively available online because they are unregulated supplements.

Anabolic steroids (which are illegal) also help with muscle gain — but at a dangerous cost. They interact with brain receptors to produce more androgen - a hormone responsible for the maintenance and development of muscles. But, steroids send a bunch of mixed messages to the receptors; thus confusing the brain. As a result, it can damage any organ which is hard to predict.

SARMs work much in the same manner as steroids. Meaning, they interact with androgen receptors to start producing more muscles. But, because they are selective, they don’t throw in a whole bunch of signals to the brain. They work ‘selectively’ which makes them safer alternatives; something gym lovers and bodybuilders has been long waiting for.

SARMs carry several benefits, including:

l Promote and Maintain Lean Muscle Growth

l Better Strength Gains

l Quicker Fat Loss

l Improved Athletic Performance

 

Southern SARMs ( Selective Androgen Receptor Modulators ) - Low Testosterone Signs and Symptoms in Males

Southern SARMs ( Selective Androgen Receptor Modulators ) says Testosterone is a sex hormone often associated with males, though females have small amounts. If a male has a low level of testosterone, the symptoms can include erectile dysfunction, and reduced bone mass and sex drive. The hormone has many important functions, including:

l The development of the bones and muscles.

l The deepening of the voice, hair growth, and other factors related to appearance.

l The production of sperm

1. Problems with erections

Low testosterone can make it difficult to get or maintain erections. Testosterone stimulates the penile tissues to produce nitric oxide, which starts several reactions that result in an erection. If levels of the hormone are too low, a man may not be able to get an erection.

2. Hair loss

Many men experience Hair loss as a natural part of aging, and age-related hair loss can also affect women. Testosterone implants supported the regrowth of hair in some women who were receiving treatment for symptoms of sex hormone deficiency.

3. Reduced bone mass

Testosterone helps to produce bone tissue and maintain bone volume. Low testosterone can lead to a reduction in this volume, which can make the bones more susceptible to Fractures.

4. Reduction in testicle size

Male with low testosterone may notice a reduction in the size of their testicles that is not related to cold temperatures. The scrotum may also feel softer than usual.

5. Reduction in the amount of semen

Semen is the fluid that makes up the majority of male ejaculate. This type of fluid helps the sperm move toward the egg. Testosterone helps stimulate the production of semen, and reduced levels of semen can indicate a reduction in testosterone. It can also lead to trouble with fertility.

6. Difficulty sleeping

Men with low testosterone may find it difficult to fall or stay asleep. Many males with low testosterone also have sleep apnea. This potentially severe disorder causes a person to temporarily stop breathing, which can disrupt sleep.

7. Lowered sex drive

Men with low testosterone often experience a reduction in sex drive. A diminishing sex drive occurs naturally with age, but when the cause is low testosterone, a man will notice a significant decrease in the desire for sex.

8. Reduced muscle mass

Testosterone plays a role in the development of muscle mass, and reduced levels of the hormone can result in a significant loss of muscle mass. Low testosterone causes a decrease in mass, the function and strength of the muscles do not diminish.

9. Hot flashes

10. A decrease in energy levels

Low testosterone can lead to reduced levels of energy and fatigue. A person may feel tired, even after adequate rest, or they may develop a diminished interest in exercise or movement.

11. An increase in body fat

A reduction in testosterone can lead to an increase in body fat. In some cases, men with a deficiency of the hormone develop gynecomastia, which causes an enlargement of the breasts.

12. Changes in mood or mood swings

Some evidence suggests that men with low levels of testosterone are likely to experience a lack of focus, irritability, and depression.

Southern SARMs (Selective Androgen Receptor Modulators) Various Ways to Review Low testosterone in women

Southern SARMs (Selective Androgen Receptor Modulators) Review low testosterone in women is as common as it is in men, and symptoms of an imbalance are similar. Testosterone is considered an androgen (a male sex related hormone), but women do also have testosterone, although much lower levels than men. It is produced in the ovaries, adrenal glands and fat cells. Just like with men, women’s testosterone levels begin to wane in the late twenties/early thirties and continue to decline with aging. Testosterone levels to drop suddenly or more rapidly such as having a hysterectomy, especially if the ovaries are removed, and dysfunction of the adrenal glands or pituitary gland. Adrenal fatigue is a common cause of dysfunction that can affect hormone levels; this is usually caused by a combination of chronic, high stress levels and poor dietary habits.

Southern SARMs: Symptoms of low testosterone in women include:

· Decreased libido

· Reduced strength, endurance, muscle tone

· Increased weight gain, especially around abdominal area

· Dry and/or thinning skin

· Sleep disturbances

· Fatigue

· “Low” mood

· Decreased energy levels

· Overall lack of motivation

· Fertility problems

· Irregular menstrual cycles

· Hair loss (usually “patchy” and all over the head)

· Increased anxiety levels

· Difficulty concentrating

· Changes in bone density levels

Southern SARMs: Some women have too much testosterone and it’s just as important to see a doctor for this as it is for low testosterone. Symptoms can include:

· Excess body hair

· Excess hair on chin or upper lip

· Deepening voice

· Acne and/or oily skin

· Balding around hairline

· Increased muscle mass/change in body shape

· Absence of periods