Wednesday, February 17, 2021

Southern SARMs - Selective Androgen Receptor Modulators Therapies with Advantages

Southern SARMs most recent discovery of non-steroidal says that selective androgen receptor modulators (SARMs) provides a promising alternative for testosterone replacement therapies with advantages including oral bio-availability, flexibility of structural modification, androgen receptor specificity, tissue selectivity, and the lack of steroid-related side effects.

The beneficial effects of testosterone on muscle, bone, and physique have been known for over a century. Yet testosterone and its esters are approved for only a limited number of therapeutic applications, including primary or hypogonadotropic hypogonadism and delayed puberty. Testosterone and structurally-related anabolic steroids have been demoted to the therapy of final resort for anemia, endometriosis, and metastatic breast cancer owing to the recent development and widespread clinical use of more effective therapies. Recent interest in using testosterone as hormone replacement in aging men or in age-related frailty has been slowed because of widespread concerns related to the effects of testosterone on the prostate, serum lipids, and cardiovascular system. The discovery and clinical development of selective estrogen receptor modulators (SERMs) transformed the therapeutic use of estrogens. Non steroidal selective androgen receptor modulators (SARMs) with the ability to selectively stimulate or maintain muscle and bone mass with lesser pharmacologic effects in the prostate are now leading a similar revolution in the therapeutic use of androgens.

Circulating testosterone is synthesized and secreted by the Leydig cells in the testes. Circulating testosterone is essential for the differentiation and growth of male accessory reproductive organs (e.g., prostate and seminal vesicles), control of male sexual behavior, and the development and maintenance of male secondary characteristics that involve muscle, bone, larynx, and hair. For decades, androgens have been primarily used for hormonal replacement in hypogonadal men. Whereas severe hypogonadism is uncommon, disease and aging-related androgen insufficiency is much more frequent. Low endogenous testosterone concentrations are associated with sarcopenia and frailty arising from decreased fat-free mass, lessened muscle strength, and reduced bone mineral density (BMD). The potential benefits of testosterone replacement therapy include increase in BMD, improvement in body composition and strength, sexual function, cognitive function, and mood; however, the potential risks of such treatment, including those in the cardiovascular system, blood and prostate are routinely experienced. Large-scale and long-term clinical trials are needed to evaluate the risk–benefit ratio of testosterone replacement therapy in aging men. Another important line of research using testosterone is hormonally mediated male contraception. A variety of attempts have been made to produce pharmacologic, effective, reversible and side effect–free contraceptive methods for the male. Hormonal male contraception has only recently reached the stage of clinical development.

Bone is a living tissue, which is continuously being broken down and regenerated by osteoclasts and osteoblasts, respectively. AR ligands affect BMD by changing overall osteoblastic activity and osteoclastic activity, resulting from changes in the total number of each cell type and individual cell functional capacity. These actions are mediated directly by the AR and by paracrine and autocrine action. The underlying mechanisms for paracrine and autocrine action have been reviewed in detail elsewhere. Androgens seem to have the ability to decelerate the bone remodeling cycle and tilt the focal balance of the cycle toward bone formation. The loss of androgens is thought to increase the rate of bone remodeling by removing restraining effects on osteoblastogenesis and osteoclastogenesis. Also, androgens exert dual effects on the lifespan of mature bone cells, with anti-apoptotic effects on osteoblasts and osteoclasts and pro-apoptotic effects on osteoclasts. DHT also stimulates osteoblast proliferation under experimental conditions

Wednesday, February 10, 2021

Georgia Southern SARMs Define Symptoms to Recognize Low Testosterone

Georgia Southern SARMs ( Selective Androgen Receptor Modulators ) Symptom for low testosterone in women can be similar to other conditions such as Hypothyroidism, Depression, Iron deficiency, and low levels of other hormones such as estrogen and progesterone so it’s always important to have all hormone levels checked, including thyroid, to determine what’s causing symptoms. Lab tests will give the full “story” of what’s going on.

Though it’s much less common, some women have too much testosterone and it’s just as important to see a doctor for this as it is for low testosterone. Symptoms can include:

Excess body hair

Excess hair on chin or upper lip

Deepening voice

Acne and/or oily skin

Balding around hairline

Increased muscle mass/change in body shape

Absence of periods

Research and studies in the past on low testosterone in women were not consistent and findings were varied regarding testosterone therapy for women. For example, one study associated an increase in abdominal weight gain after taking testosterone, however those results have been deemed “flawed” because the women participating had other hormonal imbalances going on that were not taken into consideration.

More recently though, research is showing that testosterone therapy is important and plays a big role in both how women feel, especially in regards to their libido and staying fit, lean, and active, and in their long-term health.

Women who were given testosterone therapy lost two times more body fat and gained more muscle mass than women given a placebo. The women taking the testosterone therapy gained considerable lean muscle mass over a nine-month period (which helps you to lose weight). Both groups were on the same low-fat diet and exercise regime during the course of study.

Additionally, studies suggest that a deficiency in testosterone can be a “key predictive factor” for heart disease in menopausal women or women who have had hysterectomies, and that these women have three times more risk in developing cardiovascular disease – so treating low testosterone in women is important.

Women only need a very small percentage of testosterone supplementation compared to what men need. When testosterone is balanced, women report that they feel more like they did when they were younger and have pep in their step again, with better mood and motivation. Entering the hormonal shifts that occur with peri-menopause and menopause can really have an impact on life and it’s always rewarding to feel like oneself again!

The Renewed Vitality practitioners are experts in hormone balancing. Our lab testing is much more comprehensive than what is traditionally done by most doctors so that all areas of deficiency and imbalances can be identified so that you can feel your very best.